butabarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministration of CYP3A4 inducers may well minimize sufentanil levels and efficacy, perhaps precipitating withdrawal syndrome in people who have designed Bodily dependence to sufentanil. Discontinuation … Read More